Prince's Blood Test Results - Page 7

Absolutely and that is the key, breed and age and that is what she does. Also ask her about TSH. She will tell you not to bother running it on dogs.

I was unable to upload the file here for some reason so I had to copy and paste it instead...These are the two attachments and the last which I can not upload or copy and paste is a 10 page write up by Royal Canin Dog Food and the scientific needs of the GSD's system..

FINAL REPORT
Doctor Owner
DEANNA
Pet Name
PRINCE
Received
08/21/13
Species
Canine
Breed
German Shepherd
Sex
M
Pet Age
3 Yrs
Reported
08/21/13
Test Requested Result Case Specific General Range Units
Consult Completed


Dear Deanna: THANK YOU for the Consultation/Donation ! I have reviewed the clinical history and lab
results you sent from MSU testing on 08/15/2013. I have the following comments and suggestion​

1) Despite the ongoing clinical and behavioral episodes since puppyhood, this MSU thyroid profile has
adequate, although sub-optimal levels of thyroid hormone activity, and there were no elevated thyroid
autoantibodies, ruling out autoimmune thyroiditis, TSH is discordant (false negative, a common finding
with this test in dogs vs people) -- see attached;
2) As about 40% of skin and other tissue infections respond non-specifically to thyroxine therapy to
increase skin and hair coat turnover, he should respond metabolically and behaviorally to a 6-8 week trial
course of thyroxine ( e.g. Soloxine) at a modest dose of 0. 1 mg per 15 pounds of optimum weight
given twice daily, at least an hour before or three hours after any foods, supplements or treats containing
calcium or soy, as these foods bind thyroxine and impair it's absorption;
3) As GSDs have unique difestive requirement s , adding pre- and continuing pro -biotics is a good plan as
well as provided a source of FOS (fruto- ) and MOS (mannan- )oligosaccharides. See attsached;
4) Also, as chicken, venison and mutton are considered "hot" pro-inflammatory foods in Chinese medicine,
suggest avoiding them and using neutral or cool meats ( turkey, rabbit, goat, bison, beef, grass fed lamb).
and white colored fish in stead.
Best wishes, Jean​


CANINE TSH IMMUNOASSAY UPDATE

W’ Jean Dodds, DVM
 
 
Hypothyroidism, a failure of the thyroid gland, is the most common hormonal abnormality in dogs, causing a variety of medical problems in many breeds, including hair loss and skin infections.
 
The measurement of serum levels of the pituitary hormone thyrotropin (TSH) has been used as a reliable and sensitive screening test for thyroid glandular insufficiency in human medicine for many years, but the "first generation" assays for canine TSH (cTSH) are missing as many as 1 out of 3 cases of hypothyroidism, resulting in no improvement in diagnostic sensitivity compared to total T4 and freeT4 measurement. Furthermore, the available assays have not been sensitive enough to distinguish low values of cTSH from those in the normal range.
 
The use of cTSH for predicting canine hypothyroidism is further complicated by the fact that about 1/ 3 of thyroid regulation in the dog is controlled through growth hormone [Lee et al, 2001].
 
 
 
 
References
 
 
● Dixon RM, Graham PA, Mooney CT. Serum thyrotropin concentrations: a new diagnostic test for canine hypothyroidism.  Vet Rec  138: 594-595, 1996.
●  Jensen AL, Iversen L, Høier R, et al. Evaluation of an immunoradiometric assay for thyrotropin in serum and plasma samples of dogs with primary hypothyroidism.  J Comp Pathol 114: 339-346, 1996.
●  Iverson L, Jensen AL, Høier R, et al. Biological variation of canine serum thyrotropin (TSH) concentration. Vet Clin Pathol 28:16-19, 1999.
● Lee WM, Diaz-Espineira MM, Mol JA, Rijnberk A, Kooistra HS. Primary hypothyroidism in dogs is associated with elevated GH release.  J  Endocrinol 168:59-66, 2001.
●  Diaz-Espineira MM, J.A. Mol JA, Peeters ME, Pollak YWEA, Iversen L,van Dijk JE, Rijnberk A, Kooistra HS. Assessment of thyroid function in dogs with low plasma thyroxine concentration. J Vet Intern Med 21:25–32, 2007.
● Ferguson D. Recombinant thyrotropin: standard for the next generation of cTSH immunoassays with improved sensitivity, in development .



 
 

Very interesting, thanks for sharing. Do you plan to try the thyroxine?

Is this what she's recommending?
 

You seem more concerned about the thumbs that you do the dog.
Suggestion number four.....what a riot.

Anything but the obvious.

 

This thread is only a distraction from the original thread which is now the point.
You need to deal with the original issue which I believe to be lifestyle and behavior.

 4) Also, as chicken, venison and mutton are considered "hot" pro-inflammatory foods in Chinese medicine,
suggest avoiding them and using neutral or cool meats ( turkey, rabbit, goat, bison, beef, grass fed lamb).
and white colored fish in stead.

This is total bullshit by the way.