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by Uber Land on 07 November 2010 - 04:11
I would like to apologize to everyone, I never meant for this to turn into an attack on someone's character, and political views. it seems like you can't have any type of debate or conversation without this happening on this site.
as for the weed, a very influential person who smokes is Gandalf, and he smokes hobbit weed, said to be the best in middle earth, and I can probably guarantee Yoda smoked too.
as for the weed, a very influential person who smokes is Gandalf, and he smokes hobbit weed, said to be the best in middle earth, and I can probably guarantee Yoda smoked too.
by Prager on 08 November 2010 - 17:11
UberLand I am Libertarian. I am not against legalization of any drug. I am for liberty personal responsibility with personal consequences . So I know where you are coming from. I am just frustrated with your stubborn view. This is an important issue to me and to GSD. Otherwise I would let it go long time ago.
I am not attacking you personally. I am just trying to figure out why are you disregarding so obviously any opposing view. Look, no offense intended at all and please take what I am going to say in best possible way:.... you have not very good knowledge in genetics of breeding dogs. I am willing to teach you if you let me. I am not worrying about you threatening my business. That is really silly. I am concerned with the GSD.
Please re-read carefully this statement here:
In any eukaryote, the expression of a single gene will normally contribute to more than one phenotype in the organism. Likewise, a single phenotype in an organism is normally affected by a relatively complex combination of multiple genes being expressed and interacting. You have to remember, "gene expression" is the term given for the transcription and translation of DNA sequences that result in the production of protein and enzymes. It is these proteins and enzymes that turn around and perform the function that is dictated by their structure. Most proteins and enzymes have more than one function, thus, they effect more than one facet of the animal overall.
It is believed that the color ITSELF is not the cause of the associated health problems. Its believed that the gene expressions that result in the diluted coat color/patterns also has an effect on particular health functions of the animal. This is why the color is considered a defect. Its a defect by association so to speak. A defect nonetheless though.
This effect, of course, will differ between each breed of dog. Not to mention the difference in the effect on A COMPLETELY DIFFERENT SPECIES WITH A COMPLETELY DIFFERENT EVOLUTIONARY HISTORY.
The last part of the statement means that in other breeds it expresses itself in different way thus you can not expect it to express itself exactly the same way in dogs. However the possibility or probability for some such expression is there in any species .
Take care!
Prager Hans
http://www.alpinek9.com
I am not attacking you personally. I am just trying to figure out why are you disregarding so obviously any opposing view. Look, no offense intended at all and please take what I am going to say in best possible way:.... you have not very good knowledge in genetics of breeding dogs. I am willing to teach you if you let me. I am not worrying about you threatening my business. That is really silly. I am concerned with the GSD.
Please re-read carefully this statement here:
In any eukaryote, the expression of a single gene will normally contribute to more than one phenotype in the organism. Likewise, a single phenotype in an organism is normally affected by a relatively complex combination of multiple genes being expressed and interacting. You have to remember, "gene expression" is the term given for the transcription and translation of DNA sequences that result in the production of protein and enzymes. It is these proteins and enzymes that turn around and perform the function that is dictated by their structure. Most proteins and enzymes have more than one function, thus, they effect more than one facet of the animal overall.
It is believed that the color ITSELF is not the cause of the associated health problems. Its believed that the gene expressions that result in the diluted coat color/patterns also has an effect on particular health functions of the animal. This is why the color is considered a defect. Its a defect by association so to speak. A defect nonetheless though.
This effect, of course, will differ between each breed of dog. Not to mention the difference in the effect on A COMPLETELY DIFFERENT SPECIES WITH A COMPLETELY DIFFERENT EVOLUTIONARY HISTORY.
The last part of the statement means that in other breeds it expresses itself in different way thus you can not expect it to express itself exactly the same way in dogs. However the possibility or probability for some such expression is there in any species .
Take care!
Prager Hans
http://www.alpinek9.com
by Uber Land on 08 November 2010 - 21:11
Prager, my understanding of genetics is fine.
I am just waiting to see the study which states and proves that these colors do infact cause problems. and so far, I have not found one. I do understand your post up there, but it does not list a certain breed, or anything, just an observation. if its ok in one breed, why not in the gsd? so far no one has linked any type of health problem (except for CDA, which in gsd is very mild cases, just a little thinning on the ears and muzzle) in this breed to those colors.
Dobermans and pits have a major problem with dilute colors, we all know that, but there are many other breeds which have non. many other closely related breeds for that matter.
anything is possible or probable when you discuss a living creature.
I am just waiting to see the study which states and proves that these colors do infact cause problems. and so far, I have not found one. I do understand your post up there, but it does not list a certain breed, or anything, just an observation. if its ok in one breed, why not in the gsd? so far no one has linked any type of health problem (except for CDA, which in gsd is very mild cases, just a little thinning on the ears and muzzle) in this breed to those colors.
Dobermans and pits have a major problem with dilute colors, we all know that, but there are many other breeds which have non. many other closely related breeds for that matter.
anything is possible or probable when you discuss a living creature.
by Uber Land on 08 November 2010 - 21:11
Not to mention the difference in the effect on A COMPLETELY DIFFERENT SPECIES WITH A COMPLETELY DIFFERENT EVOLUTIONARY HISTORY.
So the above qoute is agreeing that we can not use the studies done on rodents which you supplied us with in previous posts? If I can't compare the quarter horse study done on dilutes and double dilutes which shows little to no problems with these colors, I don't see how you can use the rodent studies as proof of genetic problems with blue and liver gsd.
by Prager on 08 November 2010 - 21:11
I have for you one word;
Degeneration.
Dilution is a degeneration which leads to
problems in many species. Thus expect it eventually in dogs too. That is the point.
Have a nice day. I am done.
Hans
Degeneration.
Dilution is a degeneration which leads to
problems in many species. Thus expect it eventually in dogs too. That is the point.
Have a nice day. I am done.
Hans
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